Amniotic and placental tissues are a rich natural source of human ExtraCellular Matrix (ECM) and connective tissue components. The ECM contains a protein system that provides the foundation for the body’s tissues and organs.[1,2] The placental ECM is unique, in that its young, viable proteins have not deteriorated throughout the life cycle of the body.

Physical Covering
Amniotic membranes provide an ideal human tissue membrane that covers, protects, and provides natural gliding capabilities between tissues.[3,4]

Natural Source of Growth Factors
Growth factors contained in the ECM include PDGF, VEGF, EGF, FGF and TGF-B.[8]

Scaffold Components
The ECM also contains Collagens I, III, IV, V, VI, VII, fibrous proteins that provide a structural scaffold.[5,6] Fibronectin, integrins, laminins, and hyaluronans also play a key role in adherence to the scaffold.[7-9]


Naturally Anti-Inflammatory
Amniotic membranes are shown to contain naturally anti-inflammatory properties, which may limit the risk of fibrous tissue growth and potential scar tissue formation.[11,12]

Amniotic membranes are ‘immune-privileged’, possessing little or no risk of foreign body reaction, which can lead to fibrosis and graft failure.[13]

Application of amniotic membrane as a wound covering has been shown to reduce bacteria counts in the wound, demonstrated against a wide range of bacteria.[14]


1-14 Data on file.